AMPA Agonist, CMPA
N,N′-(2,2′-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
产品信息
Form Off-white powder
Molar mass 376.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C16H28N2O4S2
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |