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AMPA Agonist, CMPA

产品编号: 155306-5MG     查看说明书
产品名称: AMPA Agonist, CMPA  .0   订购此产品 
供应商: Merck
规格: ***
目录价: 1,685.00
库存状态: 3周到货
CAS编号:
应用范围: 生化实验
种属来源:
相关信息:

AMPA Agonist, CMPA
N,N′-(2,2′-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
产品信息
Form  Off-white powder
Molar mass  376.5
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥98% by HPLC
Solubility  DMSO
Chemical formula  C16H28N2O4S2
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

保存条件: 2°C - 8°C
说明书地址: 点击查看详细
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