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PI 3,4-K inhibitor, PIK-93
N-(5-(4-Chloro-3-(((2-hydroxyethyl)amino)sulfonyl)phenyl)-4-methyl-2-thiazolyl)-acetamide
A cell-permeable phenylthiazole compound that acts as a potent, reversible and ATP-competitive PI 3,4-K family selective inhibitor (IC50 = 16, 19, 39 and 64 nM for p110γ, PI 4-KIIIβ, p110α and DNA-PK, respectively). Moderately inhibits p110δ, PI 3-KC2β, hsVPS34, ATM, p110β and PI 4-KIIIα (IC50 = 0.120, 0.140, 0.320, 0.490, 0.590 and 1.1 µM, respectively) with minimal inhibition towards a panel of 36-kinases (IC50 > 10 µM). Shown to block ceramide transfer protein-mediated ceramide traffic between endoplasmic reticulum and Golgi in transfected COS-7 cells at 250 nM.
产品信息
Form Pale yellow solid
Molar mass 389.9
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C14H16ClN3O4S2
CAS number 593960-11-3
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |