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PIM-Kinase Inhibitor IX, SGI-1776
N-((1-Methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, 2H2SO4
A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50 = 7, 363, 69, 44 and 34 nM, respectively) with moderate (40% inhibition at 1 µM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10 µM).
产品信息
Form Off-white powder
Molar mass 601.6
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥99% by HPLC
Solubility DMSO or H2O
Chemical formula C20H22F3N5O • 2H2SO4
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |