InSolution™ Chk2 Inhibitor II 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available. 产品信息 Form Liquid Formulation Supplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO. Molar mass 363.8 Protect from Light 是的 Hygrocopic 是的 Avoid freeze/thaw 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Chemical formula C20H14ClN3O2 CAS number 516480-79-8 商店和运输信息 Storage -20°C Ship Dry Ice Only Irritant 安全标示 S Phrase S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. R Phrase R: 36/38 Irritating to eyes and skin.