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YC-1
A soluble guanylyl cyclase (sGC) activator
Product Overview
Product Name: YC-1
Alternate Name/Synonyms: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
Description: Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.
Peptide Sequence: N/A
Appearance: White to pale yellow solid
Formulation: N/A
CAS Number: 170632-47-0
Molecular Formula: C₁₉H₁₆N₂O₂
Molecular Weight: 304.34
Purity: ≥98% by NMR
Solubility:DMSO (100 mM) or EtOH (50 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
InChi: InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
InChi Key: OQQVFCKUDYMWGV-UHFFFAOYSA-N
PubChem CID: 5712
MDL Number: MFCD06407798
USAGE: For Research Use Only! Not For Use in Humans. |