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GSK-2126458
A PI3 Kinase inhibitor
Product Overview
Product Name: GSK-2126458
Alternate Name/Synonyms: 2,4-Difluoro-N-{2-(methyloxy)-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl}benzenesulfonamide
Description: Cell-permeable. A highly potent, pan phosphoinositide 3-kinase (PI 3-K) family kinase inhibitor with biochemical Ki’s of 0.019 nM (PI 3-K⍺), 0.13 nM (PI 3-Kβ), 0.024 nM (PI 3-Kδ), 0.06 nM (PI 3-Kɣ), 0.18 nM (mTORC1), and 0.3 nM (mTORC2). In vivo, GSK2126458 displays anti-tumor activity in both pharmacodynamic and tumor growth efficacy models.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1086062-66-9
Molecular Formula: C₂₅H₁₇F₂N₅O₃S
Molecular Weight: 505.5
Purity: ≥98% by HPLC
Solubility:DMSO (~ 5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
InChi: InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3
InChi Key: CGBJSGAELGCMKE-UHFFFAOYSA-N
PubChem CID: 25167777
MDL Number: MFCD16038929
USAGE: For Research Use Only! Not For Use in Humans. |