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GSK-1120212
A potent and selective allosteric MEK1 inhibitor
Product Overview
Product Name: GSK-1120212
Alternate Name/Synonyms: N-[3-[3-Cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]acetamide; JTP-74057
Description: A potent and selective allosteric inhibitor of the MEK1 (IC₅₀ = 0.7 nM) and MEK2 (IC₅₀ = 0.9 nM) enzymes with potential antineoplastic activity.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 871700-17-3
Molecular Formula: C₂₆H₂₃FIN₅O₄
Molecular Weight: 615.39
Purity: ≥98% by HPLC
Solubility:DMSO (~ 10 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
InChi: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChi Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
PubChem CID: 11707110
MDL Number: MFCD17215075
USAGE: For Research Use Only! Not For Use in Humans. |