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Doramapimod
A potent p38 MAP kinase inhibitor
Product Overview
Product Name: Doramapimod
Alternate Name/Synonyms: 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BRRB 796
Description: Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 285983-48-4
Molecular Formula: C₃₁H₃₇N₅O₃
Molecular Weight: 527.66
Purity: ≥98% by HPLC
Solubility: DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
InChi: InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChi Key: MVCOAUNKQVWQHZ-UHFFFAOYSA-N
PubChem CID: 156422
MDL Number: MFCD09752957
USAGE: For Research Use Only! Not For Use in Humans. |