|
GSK-3 Inhibitor, AR-A014418
A selective GSK-3 inhibitor
Product Overview
Product Name: GSK-3 Inhibitor, AR-A014418
Alternate Name/Synonyms: N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Description: Cell-permeable. A selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC₅₀ = 104 nM). Inhibition is competitive with respect to ATP (Ki = 38nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC₅₀ values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 487021-52-3
Molecular Formula: C₁₂H₁₂N₄O₄S
Molecular Weight: 308.31
Purity: ≥98% by TLC
Solubility:DMSO (30 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
InChi: InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
InChi Key: YAEMHJKFIIIULI-UHFFFAOYSA-N
PubChem CID: 448014
MDL Number: MFCD08277040
USAGE: For Research Use Only! Not For Use in Humans. |