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Robotnikinin
A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling
Product Overview
Product Name: Robotnikinin
Alternate Name/Synonyms: N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5, 12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Description: A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first-characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a subsequent factor of the hedgehog signaling cascades. Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a Kd of 9 µM.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₂₇ClN₂O₄
Molecular Weight: 454.95
Purity: ≥97% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: C1CC(=O)OC(CNC(=O)C(CC=C1)CC(=O)NCC2=CC=C(C=C2)Cl)C3=CC=CC=C3
InChi: InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2+/t20-,22-/m0/s1
InChi Key: DRDSZZCLAHXSAE-BQIDRLATSA-N
PubChem CID: 25109985
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |