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TG003
A potent, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk)
Product Overview
Product Name: TG003
Alternate Name/Synonyms: (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
Description: Cell-permeable. A potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk) (Ki = 10 nM for mClk1/Sty; IC₅₀ = 20 nM, 200 nM, >10 µM, and 15 nM for mClk1, mClk2, mClk3, and mClk4, respectively). Recently, it has been shown that TG003 promotes the skipping of exon 31 in the endogenous dystrophin gene in a dose-dependent manner and increases the production of the dystrophin protein.
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 300801-52-9
Molecular Formula: C₁₃H₁₅NO₂S
Molecular Weight: 249.33
Purity: ≥98% by TLC
Solubility:DMSO (>30 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CCN1C2=C(C=CC(=C2)OC)SC1=CC(=O)C
InChi: InChI=1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3
InChi Key: BGVLELSCIHASRV-UHFFFAOYSA-N
PubChem CID: 647991
MDL Number: MFCD00624584
USAGE: For Research Use Only! Not For Use in Humans. |