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Kenpaullone
A potent CDK inhibitor
Product Overview
Product Name: Kenpaullone
Alternate Name/Synonyms: 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Description: Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC₅₀ = 400 nM), CDK2/cyclin A (IC₅₀ = 680nM) , CDK5 (IC₅₀ = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC₅₀ = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway.
Peptide Sequence: N/A
Appearance: Tan solid
Formulation: N/A
CAS Number: 142273-20-9
Molecular Formula: C₁₆H₁₁BrN₂O
Molecular Weight: 327.18
Purity: ≥98%
Solubility:DMSO (>25 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br
InChi: InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
InChi Key: QQUXFYAWXPMDOE-UHFFFAOYSA-N
PubChem CID: 3820
MDL Number: MFCD02683595
USAGE: For Research Use Only! Not For Use in Humans. |