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SMER28
A positive regulator of autophagy
Product Overview
Product Name: SMER28
Alternate Name/Synonyms: Small-Molecule Enhancer of Rapamycin-28;6-Bromo-4-allylaminoquinazoline
Description: Cell permeable. Acts as a positive regulator of autophagy, acting via mTOR-independent mechanism. SMER28 increases autophagosome synthesis and enhances the clearance of model autophagy substrates such as A53T a-synuclein and mutant huntingtin fragments. It is also protective in Drosophila model of Huntington’s Disease (HD).
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 307538-42-7
Molecular Formula: C₁₁H₁₀BrN₃
Molecular Weight: 264.12
Purity: ≥98% by TLC
Solubility:DMSO (~8 mg/ml) or EtOH (~ 2 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C=CCNC1=NC=NC2=C1C=C(C=C2)Br
InChi: InChI=1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
InChi Key: BCPOLXUSCUFDGE-UHFFFAOYSA-N
PubChem CID: 1560402
MDL Number: MFCD02166825
USAGE: For Research Use Only! Not For Use in Humans. |