|
DAPT
A γ-secretase inhibitor
Product Overview
Product Name: DAPT
Alternate Name/Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
Description: Cell permeable. A potent inhibitor of γ-secretase (IC₅₀ = 115 nM for total β-amyloid, IC₅₀ = 200 nM for β-amyloid 1-42). It reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young and aged Tg2576 mice. Antagonizes Notch signaling through inhibition of Notch processing. DAPT treatment can influence hematopoietic cell fate decisions and enhances neuronal differentiation in embryonic stem cell-derived embryoid bodies independent of sonic hedgehog (shh) signaling.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 208255-80-5
Molecular Formula: C₂₃H₂₆F₂N₂O₄
Molecular Weight: 432.46
Purity: ≥98% by TLC
Solubility:DMSO (~20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChi: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
InChi Key: DWJXYEABWRJFSP-XOBRGWDASA-N
PubChem CID: 5311272
MDL Number: MFCD04974585
USAGE: For Research Use Only! Not For Use in Humans. |