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8-Br-cAMP
A PKA activator
Product Overview
Product Name: 8-Br-cAMP
Alternate Name/Synonyms: 8- Bromoadenosine- 3', 5'- cyclic monophosphate; cyclic 8- bromoadenosine- 3', 5'- monophosphate; 8- bromoadenosine- 3', 5'-Monophosphate
Description: A cell-permeable cAMP analog that is more resistant to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells. Also recently shown to improve the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells 2-fold.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 76939-46-3
Molecular Formula: C₁₀H₁₀BrN₅O₆P. Na
Molecular Weight: 430.08
Purity: ≥98% by TLC
Solubility:H₂O (~100 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from moisture and light
SMILES: C1C2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]
InChi: InChI=1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1
InChi Key: DMRMZQATXPQOTP-UHFFFAOYSA-M
PubChem CID: 23712387
MDL Number: MFCD00005844
USAGE: For Research Use Only! Not For Use in Humans. |