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PD325901
Description
A potent inhibitor of MEK, a key component of the Mitogen activated protein kinase (MAPK) cascade. It has been found to inhibit tumor cell growth, has antiangiogenic and antiproliferative activities.
Specifications
Cas No. 391210-10-9
Product ID P1202
Product Name PD325901
Formula Wt. 482.19
Solubility Soluble in DMSO at 12 mg/mL; soluble in ethanol at 6.3 mg/mL with slight warming; very poorly soluble in water
References Barret, S.D., Bridges, A.J., Dudley, D.T., et al. Bioorg Med Chem Lett 18: 6501-6504 (2008). Ciuffreda L, Del Bufalo D, Desideri M, et al. Neoplasia, 11:720-731, (2009).
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