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R)-Bromoenol lactoneExclusive
Cayman Chemical Item Number 10006800
Description
The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.1↗ The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2γ. Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.2↗ (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.
Synonyms (R)-BEL
Formal Name 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl)-2H-pyran-2-one
CAS Number 478288-90-3
Molecular Formula C16H13BrO2
Formula Weight 317.2
Formulation A solution in methyl acetate
Purity ≥98%
λmax 222, 280 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES Br/C=C(CC1)/OC([C@@]1([H])C2=CC=CC3=CC=CC=C32)=O
InCHI Code 1S/C16H13BrO2/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-7,10,15H,8-9H2/b12-10+/t15-/m1/s1
InCHI Key BYUCSFWXCMTYOI-HBIYDYFMSA-N |