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Capsaicin
Cayman Chemical Item Number 92350
(CAS 404-86-4)
Description
Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1↗ Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2↗ VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3↗ Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.
Formal Name:N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide
CAS Number:404-86-4
Molecular Formula:C18H27NO3
Formula Weight:305.4
Formulation:A crystalline solid
Purity:≥95%
λmax:230, 281 nm
Stability:2 years
Storage:-20°C
Shipping:Room temperature in continental US; may vary elsewhere
SMILES:COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O
InCHI Code: 1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InCHI Key: YKPUWZUDDOIDPM-SOFGYWHQSA-N |