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Capsaicin (technical grade)
Cayman Chemical Item Number 10010743
Description Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1↗ Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2↗ VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3↗ Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.
Formal Name N-[(4-hydroxy-3-methoxyphenyl)methyl]-6E-8-methyl-nonenamide
CAS Number 404-86-4
Molecular Formula C18H27NO3
Formula Weight 305.4
Formulation A crystalline solid
Purity >60%
λmax 230, 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O |