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CAY10433
Cayman Chemical Item Number 10005019
Description
Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation.1↗ CAY10433 is a small molecule inhibitor of HDAC with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate2↗ (substrate available in Cayman’s HDAC Activity and Inhibitor Screening Assay Kits - Item Nos. 10011563 and 10011564). CAY10433 also inhibits the deacetylation of the transcription factor FOXO3 by mammalian SIRT1 in cells oxidatively stressed by hydrogen peroxide.3↗
1 Yoshida, M., Kijima, M., Akita, M., et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265(28) 17174-17179 (1990).
2 Johnson, J. BK617. (2007).
3 Brunet, A., Sweeney, L.B., Sturgill, J.F., et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303 2011-2015 (2004).
Synonyms N-phenyl-N'-(2-Aminophenyl)hexamethylenediamide
BML-210
Formal Name N-(2-aminophenyl)-N'-phenyl-octanediamide
CAS Number 537034-17-6
Molecular Formula C20H25N3O2
Formula Weight 339.4
Formulation A crystalline solid
Purity ≥95%
λmax 241 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(CCCCCCC(=O)Nc1ccccc1N)Nc1ccccc1
InCHI Code 1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25)
InCHI Key RFLHBLWLFUFFDZ-UHFFFAOYSA-N |