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CAY10435
Cayman Chemical Item Number 10005102
Description
Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.57 nM.1↗ Using a proteonomics approach, CAY10435 was screened against the serine hydrolase family of enzymes, of which FAAH is a member. In this assay, CAY10435 exhibited IC50 values of 0.81 nM, 83 nM, and 50 µM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively.2↗ Knowledge of the specificity of CAY10435 obtained from this experiment should allow for more accurate interpretation of results using the inhibitor in complex environments such as whole cells or animals.
1 Boger, D.L., Sato, H., Lerner, A.E., et al. Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide. Proc Natl Acad Sci USA 97 5044-5049 (2000).
2 Leung, D., Hardouin, C., Boger, D.L., et al. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nat Biotech 21(6) 687-691 (2003).
Formal Name 1-oxaxolo[4,5-b]pyridin-2-yl-1-dodecanone
CAS Number 288862-73-7
Molecular Formula C18H26N2O2
Formula Weight 302.4
Formulation A solution in methyl acetate
Purity >98%
λmax 235, 296 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES CCCCCCCCCCCC(=O)c1oc2cccnc2n1
InCHI Code 1S/C18H26N2O2/c1-2-3-4-5-6-7-8-9-10-12-15(21)18-20-17-16(22-18)13-11-14-19-17/h11,13-14H,2-10,12H2,1H3
InCHI Key XUWBDQAPIZBSRY-UHFFFAOYSA-N |