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Poly(I:C) (HMW) VacciGrade™
Poly(I:C) is a synthetic double-stranded RNA, that can activate the immune response through two distinct PRRs. Endosomal poly(I:C) activates TLR3 while cytosolic poly(I:C) activates RIG-I/MDA-5. Triggering the TLR3 pathway induces IL-12 and type I IFNs production, while stimulation of MDA-5 enhances the production of type I IFNs. Poly(I:C) promotes Th1 biased immunity through its induction of IL-12 and type I IFNs.
Poly(I:C) VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile and thoroughly tested for the presence of endotoxins.
Poly(I:C) VacciGrade™ is for research use only, not for use in humans.
Specificity: Th1 response
Working concentration: 10 - 100 μg/mouse
Endotoxin level: <1 EU/mg
Solubility: 5 mg/ml in physiological water (NaCl 0.9%) heated for 10 minutes at 65 - 70°C |