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MPLA Synthetic VacciGrade™
Synthetic lipid A
Synthetic lipid A from E. coli, serotype R515 (MPLAs) is a pure monophosphoryl lipid A compound produced by chemical synthesis.
MPLAs activates TLR4 but does not activate TLR2 reflecting its high purity. MPLAs contains 6 fatty acyl groups, while MPLA purified from bacteria contains a mixture of 5, 6, and 7 acyl lipid A.
MPLA has been tested as an adjuvant in mice and reported to induce a strong Th1 response.
MPLAs VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile and thoroughly tested for the presence of endotoxins.
MPLAs VacciGrade™ is for research use only, not for use in humans.
Specificity: TLR4 agonist - Th1 response
Working concentration: 2- 20 μg/mouse
Molecular weight: 1763.47
CAS Number: 1246298-63-4
Solubility: 1 mg/ml in DMSO
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