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AddaVax™
Vaccine Adjuvant: Squalene-Oil-in-water
AddaVax™ is a squalene-based oil-in-water nano-emulsion with a formulation similar to MF59® that has been licensed in Europe for adjuvanted flu vaccines [1].
Squalene is an oil more readily metabolized than the paraffin oil used in Freund’s adjuvants [1]. Squalene-based oil-in-water nano-emulsions promote a significant increase in antibody titers with reportedly more balanced Th1/Th2 responses than those obtained with alum [2]. This class of adjuvants is believed to act through recruitment and activation of APC and stimulation of cytokines and chemokines production by macrophages and granulocytes [1].
AddaVax™ is VacciGrade™ (preclinical grade) for research use only, not for use in humans.
The mark MF59® is a registered trademark of Novartis, and is used for comparative purposes only. AddaVax™ is not made by, affiliated with, sponsored by or endorsed by Novartis. Novartis has not evaluated or approved the representations contained herein.
Specificity: Th2 response
Working concentration: 1:1 (addaVax:antigen)
Endotoxin level: < 5 EU/ml
Appearance: Off-white emulsion |