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2-Aminopurine
PKR Inhibitor
2-aminopurine (2-AP) is a potent inhibitor of double-stranded RNA (dsRNA)-activated protein kinase (PKR), a critical mediator of apoptosis. PKR is phosphorylated and activated by dsRNA and poly(I:C) [1] and contributes to the induction of type I interferons, such as IFN-β, which can further increase its expression [2]. PKR plays also a role in TLR-induced antiviral activities as an intermediary in TLR3, TLR4 and TLR9 signaling [3].
Working concentration: 1 - 10 mM
Purity: >98% TLC
CAS number: 452-06-2
Synonym: 2-Aminopurine
Molecular weight: 135.1
Solubility: 20 mg/ml in phosphate-buffered saline:glacial acetic acid (200:1) with heating at 65°C for 15 minutes
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