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5-Fluorouracil (5-FU)
Nucleobase analog for in vitro and in vivo cytotoxicity assays
5-Fluorouracil is a fluorinated analog of uracil. 5-FU is approved by the U.S. Food and Drug Administration (FDA) for cancer chemotherapy as an antineoplastic, antimetabolic agent. Lately with the development of gene therapy, 5-FU can be used in combination with the uracil phosporibosyltransferase suicide gene.
CAS number: 51-21-8
Formula: C4H3FN2O2
Molecular weight: 130.1
Working concentration: 1 - 300 μg/ml
Uracil phosporibosyltransferase genes:
S.cerevisiae, E.coli
Cytosine Deaminase (CD) fused to uracil phosphoribosyl transferase genes:
S. cerevisiae, E.coli |