|
5-Fluorocytosine (5-FC)
Nucleobase analog for in vitro and in vivo cytotoxicity assays
5-Fluorocytosine is a fluorinated analog of cytosine. 5-FC is approved by the U.S. Food and Drug Administration (FDA) as an antifungal agent used for the treatment of Candida and Cryptococcus. Lately with the development of gene therapy, 5-FC has been introduced as a prodrug in combination with the cytosine deaminase suicide gene.
CAS number: 2022-85-7
Formula: C4H4FN3O
Molecular weight: 129.1
Working concentration: 200 - 500 μg/ml
Cytosine Deaminase (CD) genes:
S. cerevisiae, E.coli
Cytosine Deaminase (CD) fused to uracil phosphoribosyl transferase genes:
S. cerevisiae, E.coli |