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精胺 Spermine
英文名：O,O-Dimethyl phosphoramidothioate; O,O-Dimethyl thiophosphoramidate；spermine；gerontine；musculamin；neuridine；Spermine H2N(CH2)3NH(CH2)4NH(CH2)3NH2；
Musculamine；N,N′-Bis(3-aminopropyl)tetramethylenediamine；N,N′-Bis(3-aminopropyl)-1,4-butanediamine ；Diaminopropyltetramethylenediamine , 1,12-Diamino-4,9-diazadodecane
中文名：精胺; 精素；精碱；N,N′-双(3-氨丙基)-1,4-丁二胺,α,δ-双(γ-氨丙氨基)丁烷； 1,12-二氨基-4,9-二氮十二烷O；O-二甲基硫代磷酰胺
性质： 沸点130℃(13.3Pa)。在0～4℃保存。是含有两个氨基和两个亚氨基的多胺类物质，在生物体内由腐胺和S-腺苷蛋酸经多种酶催化后生成。它与亚精胺都存在于细菌和大多数动物细胞中，是促进细胞增殖的重要物质。在酸性条件下，它呈现出多阳离子多胺类特性，并能与病毒与细菌中DNA结合。使DNA分子具有更大的稳定性与柔韧性：也是细胞培养液中必要组分之一。
Sigma相关产品资料:
Sigma S3256 Spermine ≥97%
Synonym: N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
CAS Number: 71-44-3
Linear Formula: NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Molecular Weight: 202.34
Beilstein Registry Number: 1750791
EC Number: 200-754-2
MDL number: MFCD00008215
PubChem Substance ID: 24899550
Description
Biochem/physiol Actions Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
性质
assay ≥97%
bp 150 °C/5 mmHg(lit.)
mp 28-30(lit.)
Gene Information human ... GRIN2B(2904)
rat ... Grin2a(24409)
storage temp. 2-8°C |