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VEGFR Tyrosine Kinase Inhibitor II
N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, VEGF Receptor Tyrosine Kinase Inhibitor II, VEGFR2 Kinase Inhibitor XVII, VEGFR1 Kinase Inhibitor III
A pyridinyl-anthranilamide compound that displays both antiangiogenic and antitumor properties. A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the kinase activities of KDR, Flt-1 and c-Kit (IC50 = 20 nM, 180 nM and 240 nM, respectively), and minimally inhibit c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM). Further, inactive towards the inhibition of CDK-1, c-Met, IGF-1R and PKA (IC50 > 10 µM).
产品信息
Form White solid
Primary Target kinase activities of KDR, Flt-1 and c-Kit
Primary Target IC50 20 nM, 180 nM and 240 nM, respectively
Secondary target c-Src and EGF-R activities (IC50 = 7 µM and 7.3 µM)
Molar mass 337.8
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C19H16ClN3O
CAS number 269390-69-4
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Standard Handling |