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VEGFR2 Kinase Inhibitor I
(Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII
A highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 µM).
产品信息
Form Yellow solid
Primary Target (RTK) inhibitor
Primary Target IC50 70 nM
Molar mass 310.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C18H18N2O3
CAS number 15966-93-5
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |