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AG 879
α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.
产品信息
Form Orange-yellow solid
Primary Target (NGF)-dependent p140c-trk tyrosine phosphorylation
Primary Target IC50 EC50 = 10 µM
Molar mass 316.5
Protect from Light 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C18H24N2OS
CAS number 148741-30-4
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |