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AG 17
NSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.
产品信息
Form Pale yellow solid
Primary Target platelet-derived growth factor receptor tyrosine kinase
Primary Target IC50 500 nM
Secondary target induced tyrosine phosphorylation of PYK2
Molar mass 282.4
Protect from Light 是的
Purity ≥99% by TLC
Solubility DMSO or EtOH
Chemical formula C18H22N2O
RTECS OO3737000
CAS number 10537-47-0
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Ship Ambient Temperature Only
Toxic |