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TNF-α Inhibitor
6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, Tumor Necrosis Factor-α Inhibitor, TNF-α Inhibitor
A cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
产品信息
Form White solid
Molar mass 629.6
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C32H32F3N3O2 • 2HCl • 1/2H2O
CAS number 1049741-03-8
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |