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TNF-α Antagonist
TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.
产品信息
Peptide Sequence H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Form Lyophilized
Formulation Supplied as a trifluoroacetate salt.
Molar mass 1226.4
Hygrocopic 是的
Purity ≥95% by HPLC
Solubility H2O or 5% Acetic Acid
Chemical formula C58H71N11O15S2
Declaration Sold under license of U.S. Patent 6,265,535.
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |