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产品说明
A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
产品信息
Form Yellow solid
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C13H10BrN3O4
CAS number 182498-32-4
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |