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SB 239063
trans-1-(4-Hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)imidazole, p38 MAP Kinase Inhibitor XV
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of the α- and β-isoforms (IC50 = 44 nM), but not the γ- or δ-isoform (IC50 > 100 µM), of MAP kinase p38. It inhibits IL-1 and TNF-α production (IC50 = 120 nM and 350 nM, respectively) in LPS-stimulated human peripheral blood monocytes. Also reduces brain injury and neurological deficits in cerebral focal ischemia and reduces myocardial reperfusion injury by reducing the expression of endothelial adhesion molecule and by blocking polymorphonuclear (PMN) leukocytes accumulation.
产品信息
Form White solid
Primary Target MAPKp38α & β
Primary Target IC50 44 nM
Secondary target MAPKp38γ, MAPKp38δ (IC50 ≥ 100 mM)
Molar mass 368.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥97% by HPLC
Solubility Warm DMSO
Chemical formula C20H21FN4O2
CAS number 798558-40-4
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |