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SANT-1
Shh Signaling Antagonist V
A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway (IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells) by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay).
产品信息
Form White solid
Primary Target antagonist of the Shh (Sonic Hedgehog) signaling pathway
Primary Target IC50 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells
Secondary target activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay)
Molar mass 373.5
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C23H27N5
CAS number 304909-07-7
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |