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Safingol
L-threo-Dihydrosphingosine
A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 µM and 31 µM, respectively). Inhibits human PKCα, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 µM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis.
产品信息
Form White solid
Primary Target enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC
Primary Target IC50 37.5 mM and 31 mM, respectively
Secondary target human PKCa, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 mM)
Molar mass 301.5
Purity ≥98% by TLC
Solubility DMSO, EtOH, or MeOH
Chemical formula C18H39NO2
CAS number 15639-50-6
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Irritant |