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Rho Kinase Inhibitor III, Rockout
3-(4-Pyridyl)-1H-indole
A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC50 of 25 µM. Does not inhibit the activation of Rho kinase nor does it affect the in vitro activities of MLCK, PKCα, and SAPK2a/p38α. Shown to be 5-fold less potent than Y-27632 (Cat. No. 688000; IC50 = ~5 µM), and display a similar specificity profile as H-89 (Cat. No. 371963). Affects cell migration, inhibits blebbing (IC50 = ~ 12 µM in M2 cells), and decreases stress fibers in Bulb 3T3 cells at 50 µM.
产品信息
Form Yellow solid
Primary Target ROCK
Primary Target IC50 25 µM
Molar mass 194.2
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C13H10N2
CAS number 7272-84-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |