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Protein Methyltransferase Inhibitor, AMI-5
Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
产品信息
Form Reddish brown solid
Molar mass 745.9
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥90%
Solubility H2O
Chemical formula C29H6Br4O5Na2 • 3H2O
CAS number 17372-87-1
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant |