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Protein Arginine N-Methyltransferase Inhibitor, AMI-1
PRMT Inhibitor I
A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC50 = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM).
产品信息
Form Solid
Primary Target PRMT1
Primary Target IC50 8.81 µM
Secondary target 3.03 µM for yeast-RMT1p nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC50 = 5 µM)
Molar mass 592.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C21H12N2Na4O9S2
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |