|
PPIase-Parvulin Inhibitor
PiB, Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties (IC50 < 5 µM against a panel of human cancer cell lines). Causes cell cycle arrest and acts as a potent, selective, reversible, competitive, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity (IC50 = ~ 1.5 µM). Does not bind to DNA or functions as a topoisomerase I inhibitor.
产品信息
Form Brownish solid
Molar mass 438.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by NMR
Solubility Chloroform or EtOH
Chemical formula C22H18N2O8
CAS number 64005-90-9
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |