|
Polyphosphoinositide-Binding Peptide, PBP10
RhoB-GS160-169, Rhodamine B-QRLFQVKGRR-OH
A Rhodamine-B-labeled decapeptide derived from the (PIP2)-binding region in segment-2 of gelsolin. Acts as a cell-permeable, reversible, and non-toxic agent that transiently disrupts actin filaments, which are essential for cell morphology and cell motility (~1-10 µM). Specifically binds to polyphosphoinositide (PPI) with high affinity and activates platelet without significantly affecting intracellular Ca2+ influx. Undergoes a reduction in fluorescence intensity upon binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid; the fluorescence is not affected in the presence of phosphatidylserine and phosphatidylcholine. Useful fluorescent probe for the cellular localization and stabilization of PPIs.
产品信息
Peptide Sequence Rho-B-Gln-Arg-Leu-Phe-Gln-Val-Lys-Gly-Arg-Arg-OH
Form Pinkish red lyophilized solid
Formulation Supplied as a trifluoroacetate salt.
Molar mass 1713.1
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Excitation max. 565 nm
Emission max. 590 nm
Solubility DMSO
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |