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PI 3-Kγ/CKII Inhibitor
(5-(4-Fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione, PI 3-K Inhibitor XII, AS-252424
A cell-permeable furanyl-thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor of PI 3-Kγ and CKII (IC50 = 20 nM). It inhibits other PI 3-K isotypes (IC50 = 0.94, 20, and 20 µM for α, β, δ, respectively) and MKK7β (IC50 >10 µM) only at much higher concentrations and exhibits little activity against 77 other commonly studied kinases even at concentrations as high as 10 µM. Shown to inhibit stimulated Akt phosphorylation in cells in vitro and offer blockage of thioglycollate-induced neutrophil recruitment in a murine peritonitis model in vivo.
产品信息
Form Yellow solid
Molar mass 305.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C14H8FNO4S
CAS number 1138220-19-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |