PD 168393
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
产品信息
Form Yellow solid
Primary Target EGFR
Primary Target IC50 700 pM
Molar mass 369.2
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C17H13BrN4O
CAS number 194423-15-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |