产品说明 A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the phosphate acceptor. Has only a trivial effect on the activity of PKA and PKC (IC50 > 350 µM). Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Also inhibits topoisomerase II activity in vitro. 产品信息 Form White solid Primary Target EGFR kinase Primary Target IC50 2.6 µM Protect from Light 是的 Purity ≥95% by HPLC Chemical formula C15H10O5 RTECS NR2392000 CAS number 446-72-0 Merck USA index 14, 4391 Storage -20°C Ship Ambient Temperature Only Standard Handling