GELDANAMYCIN, STREPTOMYCES HYGROSCOPICUS

Geldanamycin, Streptomyces hygroscopicus
A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Geldanamycin has antiproliferative and antitumor effects. Rapidly depletes p185c-erbB2 protein tyrosine kinase in breast carcinoma cells. Binds to HSP90 and disrupts Raf1-HSP90 complex leading to destabilization of Raf1. Inhibits basal and hypoxia-induced expression of c-Jun (IC50 = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase activity. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines.
产品信息
Form  Yellow solid
Primary Target  pc60c-svc tyrosine kinase
Secondary target  basal and hypoxia-induced expression of c-jun (IC50 = 75 nM)
Molar mass  560.6
Protect from Light  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C29H40N2O9
RTECS  LX8920000
CAS number  30562-34-6
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling