FTI-2628 A cell-permeable benzyl ester prodrug form of FTI-2148 (Cat. No. 344557) that preferentially inhibits protein farnesyltransferase activity (IC50 = 530 nM for mammalian and 1.0 µM for P. falciparum) over protein geranylgeranyltransferase-I (IC50 > 10 µM for mammalian) and displays anti-malarial properties. Potently disrupts Ras farnesylation in H-Ras-transformed NIH 3T3 cells (IC50 = 20 nM) and inhibits the growth of P. falciparum in red blood cells (ED50 = 150 nM). Also suppresses parasitemia in P. berghei-infected mice by 46.1% (50 mg/kg, ip) with no apparent toxicity. 产品信息 Form White solid Primary Target PFTase Primary Target IC50 530 nM (mammalian) Secondary target protein geranylgeranyltransferase-I (IC50 > 10 µM for mammalian) Molar mass 542.7 Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Solubility DMSO or MeOH Chemical formula C31H34N4O3S 商店和运输信息 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Standard Handling