FTI-276 A highly potent and selective CAAX peptidomimetic of the carboxyl terminal of Ras proteins that inhibits farnesyl transferase (FTase) in vitro (IC50 = 500 pM). Inhibits geranylgeranyltransferase I (GGTase I) at much higher concentration (IC50 = 50 nM). Has been shown to selectively block the growth of a human lung carcinoma expressing oncogenic K-Ras in nude mice. Also inhibits oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the Ras oncogene at 20 µM. 产品信息 Form White solid Formulation Supplied as a trifluoroacetate salt. Primary Target FTase in vitro Primary Target IC50 500 pM Secondary target GGTase 1 (IC50 = 50 nM) Molar mass 433.6 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥90% by HPLC Solubility DMSO Chemical formula C21H27N3O3S2 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling