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Chetomin, Chaetomium sp.
A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain.
产品信息
Form Off-white solid
Molar mass 710.9
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C31H30N6O6S4
RTECS FM3038000
CAS number 1403-36-7
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Toxic |